DM DERMATOLOGY
Rejuran
REJURAN
Rejuran works from within the dermis
to help care for facial aging,
skin damage, and elasticity
Rejuran is a skin booster that places polynucleotide (PN), an ingredient obtained from salmon, into the dermis to care for skin texture and elasticity.
Rejuran
Skin booster · Rejuran
This treatment delivers a bio-derived compound directly into the dermis, the inner layer of the skin. By delivering polynucleotide (PN) to the dermis, it aims to improve the foundation of damaged skin, and it helps collagen production.
With age and built-up UV exposure, collagen in the dermis decreases. The skin then becomes thinner, fine lines increase, and texture turns rough. Rejuran is different from filler, which fills hollow areas to change their shape. It cares for the skin's foundation over several sessions, so changes appear gradually.
At DM Dermatology in Apgujeong, a board-certified dermatologist first looks at your skin thickness, the depth of your wrinkles, and any treatments you will have alongside it. Then we choose the right product and number of sessions from Rejuran Healer, Rejuran HB, Rejuran i, and Rejuran S. The degree of change and how long it lasts vary from person to person.
- Elasticity care
- Texture care
- Dermal environment care
- Salmon-derived PN
2~3wk
Treatment interval
3sessions
Sessions per course
4
Products chosen by area
48h
Time to avoid strong UV
CHECK LIST
Do you have these
skin concerns?
- Elasticity
“My skin has lost its firmness, and it bothers me”
- Pores · oil
“Pores and oil make my skin look unclean…”
- How long it lasts
“I worry the effect will only be temporary”
- Wrinkles
“The wrinkles on my face make me look so much older…”
Rejuran is a skin booster that helps care for skin texture and elasticity. Its purpose differs from lifting treatments that raise sagging skin. For enlarged pores or deep wrinkles, laser or filler is sometimes planned as well.
HOW IT WORKS
The salmon-derived
DNA ingredient, PN
Rejuran's main ingredient is PN, a long, chain-shaped ingredient made by extracting and purifying DNA from salmon germ cells. When PN meets water, it forms a net-like gel.
In the dermis, PN is described as acting as a support (scaffold) between cells and as creating an environment where fibroblasts, the cells that make collagen, can work well. That is why changes from Rejuran do not happen all at once; they build up over several sessions.
- Acting as a support
PN chains form a network in the dermis that supports the area around cells.
- Holding moisture
PN binds readily with water, so it helps hold moisture in the skin.
- 1
Epidermis The outermost layer of the skin. Rejuran passes through this layer and is placed deeper.
- 2
Dermis The layer where collagen and elastic fibers gather. Rejuran is placed in small amounts in the shallow part of this layer.
- 3
PN strands Long DNA chains obtained from salmon. In the dermis, they form a network that holds moisture.
- 4
Fibroblasts Cells in the dermis that make collagen. PN is described as supporting the activity of these cells.
- 5
Collagen Protein fibers that support the skin. They decrease with age, so the skin thins and wrinkles form.
EFFECT
What Rejuran may help with
STEP 01
Promoting collagen production
Delivers polynucleotide to the dermis, aiming to improve the foundation of damaged skin, and helps collagen production
STEP 02
Skin texture improvement
Helps rough skin texture even out by holding moisture in the skin
STEP 03
Increased skin elasticity
Helps toward firm, healthy skin by caring for the environment of the dermis
Changes appear gradually over several sessions, and the degree varies from person to person.
FOUR TYPES
Four types of Rejuran
for different areas and concerns
All four products have PN as their main ingredient. They differ in viscosity and added ingredients, so we choose by treatment area and concern.
01Rejuran Healer
Rejuran Healer
The basic Rejuran product, containing PN only. It is placed in small amounts evenly through the dermis of the whole face. It is used to care for skin texture, elasticity, and fine lines together.
Who it suits- You are concerned about texture and elasticity across your face
- You are trying Rejuran for the first time
02Rejuran HB
Rejuran HB
This product adds hyaluronic acid and lidocaine, a local anesthetic, to PN. Hyaluronic acid holds moisture, and lidocaine is added to ease the sting of the injections. This product is not used if you are allergic to local anesthetics.
Who it suits- You are worried about injection pain
- You want to care for dryness and fine lines together
03Rejuran i
Rejuran i
A product for thin skin such as the eye area. Compared with Rejuran Healer, it is made with lower viscosity so it spreads easily. It is used to care for fine lines around the eyes and the texture of under-eye skin.
Who it suits- Fine lines around or under your eyes bother you
- The skin under your eyes looks thin
04Rejuran S
Rejuran S
Compared with Rejuran Healer, this product has higher viscosity and spreads less. It tends to stay where it is placed, so it is used to focus on specific areas. It is considered for small depressed areas such as acne scars, or for fine lines that have deepened.
Who it suits- You have areas with depressed acne scars
- Fine lines in certain areas look deep
Which product to use, and how many cc, is decided after the doctor examines your skin. Sometimes two products are used for different areas.
Advantage
Key features of Rejuran
It does not fill or lift the skin; it cares for the foundation of the dermis.
- 01
Promoting collagen production
Collagen is made by fibroblasts in the dermis. Rejuran is described as helping collagen production by caring for the area around these cells.
- 02
Care for rough skin texture
It helps even out rough texture by holding moisture in the skin. For enlarged pores, laser treatment is sometimes planned as well.
- 03
Skin barrier care
There are reports that skin lost less moisture on the side treated with Rejuran right after laser treatment. We also use it in recovery plans for sensitized skin.
- 04
Skin texture · skin tone improvement
When skin texture is even, light reflects evenly and the skin looks clearer. Pigment conditions such as melasma may need laser treatment first, so the doctor tells them apart at your visit.
Skin Care
step by step
RECOMMEND
DM Rejuran is recommended
in these cases
- Recommended case 1You are concerned about fine lines across your face
- Recommended case 2Your skin looks thinner and dull
- Recommended case 3You want a natural-looking change
- Recommended case 4You want to start caring for skin aging
- Recommended case 5You are looking into treatments to improve wrinkles
For hollow areas or deep wrinkles, filler or Botox (botulinum toxin) may come first. Whether the treatment is right for you is decided after an examination.
PROCESS
The Rejuran treatment process
Below is the general flow. We explain the actual steps and timing during your consultation.
Examination and product choice
A board-certified dermatologist looks at your skin thickness and areas of concern, then sets the product and dose. We ask about allergies, medications, and pregnancy or breastfeeding.
Cleansing and numbing cream
We remove your makeup and disinfect the treatment area. Numbing cream is applied, followed by a 20–30 minute wait.
Injections spread through the dermis
We wipe off the numbing cream and disinfect again. Small amounts are injected at many points in the shallow layer of the dermis. The full face takes about 20–30 minutes.
Soothing and going home
Cool pads or a soothing mask calm warmth and swelling. You go home after hearing the aftercare instructions, and the next session is booked 2–3 weeks later.
INFORMATION
Rejuran treatment info
- Procedure timeInjections 20–30 minAllow another 20–30 min for numbing cream
- NumbingNumbing cream 20–30 minRejuran HB contains an anesthetic
- RecoveryBumps · redness 1–3 daysBruises, if any, last 1–2 weeks
- Daily lifeSame dayAvoid saunas, strenuous exercise, and alcohol for 1 week
- Interval · Sessions3 sessions, 2–3 weeks apartAfter the course, we discuss maintenance treatment every 6–12 months
- VolumeHealer 2cc · HB / i / S 1ccWe choose the product by area and concern
These are general guidelines and vary from person to person. DM Dermatology sets your treatment schedule after an examination.
Caution
DM Rejuran
aftercare precautions
Do not irritate the skin until injection marks and swelling settle.
- 01Limit long screen time
Avoid looking at a computer monitor for long periods.
- 02Moisturizing
Skin may feel dry after treatment, so apply lotion or cream often.
- 03Caution with UV · bright light
For about 48 hours after treatment, avoid going out when UV light is strong. Indoors, or when going out at night, avoid very bright light as well.
- 04No rubbing or scratching
You can usually wash your face, shower, and wear makeup. But take care not to rub or scratch the treated area too hard.
- 05Hands off on the day
Do not press or rub injection marks. Raised bumps settle on their own without massage.
- 06Gentle cleansing
Wash gently with lukewarm water. Skip scrubs and peeling products until the bumps settle.
- 07Light makeup
Do not rub over injection marks; pat makeup on lightly with your fingertips. If the bumps stand out, waiting until the next day reduces irritation.
- 08Tell us about other treatments
If you have laser, filler, or Botox scheduled, please tell us in advance. We will adjust the order and intervals.
- Small raised bumps may form at injection sites. Redness, swelling, itching, and tenderness to the touch may also occur. These usually settle within 1–3 days.
- Bruising may occur. It is more likely around the eyes, where the skin is thin, and may last 1–2 weeks.
- The injections sting, and how much it hurts varies by area and person. If pain gets steadily worse after treatment, contact the clinic.
- Rarely, a small lump (nodule) may be felt at an injection site, or the area may harden. If it is still there after a few weeks, come in for a check.
- Rarely, a bacterial infection may develop at an injection site. If you notice warmth, pus, or swelling that keeps growing, contact us right away.
- Rejuran is made from an ingredient obtained from salmon. Rejuran HB also contains hyaluronic acid and a local anesthetic (lidocaine). If you have ever had an allergic reaction to fish or salmon, local anesthetics, or injectable products, tell us before treatment.
- With facial injections, the injected material can, very rarely, block a blood vessel. If pain at an injection site keeps getting worse, the skin turns white or purplish, or your vision becomes blurry, contact us immediately.
- Safety during pregnancy and breastfeeding has not been established, so treatment is postponed. Tell us if you have inflammation, infection, or a skin disease in the treatment area, or an autoimmune disease. Aspirin and anticoagulants can increase bruising, but do not stop them on your own; talk first with the doctor who prescribed them.
※ Depending on the person, bruising or swelling may occur after a procedure or surgery. The degree of change, duration, and recovery time vary from person to person.
DM DOCTOR
A board-certified dermatologist as medical director
Personal diagnosis · Accountable care
Thorough care from a board-certified dermatologist with over 20 years of treating skin
At DM Dermatology, our medical director, a board-certified dermatologist, examines your skin in person and plans treatment around your concerns and daily life.
Dr. Shin Young-ik Medical Director · Board-Certified Dermatologist
- M.S., Hanyang University College of Medicine
- Adjunct Professor, Hanyang University
- Full Member, Korean Dermatological Association
- Clinical Fellowship in Dermatology, Jefferson Medical College (Thomas Jefferson University), USA
Care by a board-certified dermatologistPatients here are seen by a dermatologist certified by the Ministry of Health and Welfare
DM DERMATOLOGY
Related treatments
FAQ
01How are Rejuran Healer, Rejuran HB, Rejuran i, and Rejuran S different?
All four products have PN as their main ingredient. Rejuran Healer is the basic product with PN only, and Rejuran HB adds hyaluronic acid and lidocaine, a local anesthetic. Rejuran i is thinner than Healer and spreads easily, so it is used for thin skin such as the eye area. Rejuran S has higher viscosity than Healer and is used for specific areas such as depressed scars. Which product suits you is decided after the doctor examines your skin.
02Which areas can Rejuran treat?
The eye area · fine lines on the face · around the mouth & nasolabial folds · neck lines.
03How many sessions does it take to see results with Rejuran?
Rejuran aims to improve the skin's foundation by caring for the dermal environment, and changes appear gradually over several sessions. Treatment is usually 3 sessions, 2–3 weeks apart, and the degree of change varies from person to person.
04How long do Rejuran bumps last?
Bumps are the small raised marks at each injection point. They form because the skin swells briefly with the amount injected, and they usually settle within 1–3 days. Pressing or rubbing them can make redness last longer, so leave them alone. If they have not gone down after 3 days, or if they hurt, please let the clinic know.
05Can I go about my daily life afterward?
You can usually return to daily life the same day, and light makeup is fine. Bumps and redness may remain for 1–3 days.
06Are there any precautions after treatment?
For one week after treatment, avoiding saunas, strenuous exercise, and alcohol is good for the results. Take care with sun protection; taking antioxidants such as vitamin C is also a good idea.
07Do Rejuran injections hurt a lot?
Injections are given at many points, so they sting. Numbing cream is applied for 20–30 minutes before treatment, and if you are worried about pain, you can choose Rejuran HB, which contains lidocaine. Thin or sensitive areas, such as around the eyes or mouth, may feel more painful.
08Will it hurt after treatment?
If pain at an injection site lasts more than a day after treatment, or redness (flushing) appears, please visit the clinic.
09How is Rejuran different from filler?
Filler uses a gel such as hyaluronic acid to fill hollow areas or deep wrinkles and change their shape. Rejuran is placed in small amounts in the shallow layer of the dermis to care for the skin's foundation, such as texture and elasticity. It is not a volume-filling treatment, so if hollow areas concern you, we discuss filler as well.
10What should I tell DM Dermatology in Apgujeong before getting Rejuran?
Please tell us about any fish or salmon allergy, any local anesthetic allergy, and medications you take (especially aspirin or anticoagulants). Please also tell us about pregnancy or breastfeeding, autoimmune diseases, and recent filler or laser treatments so we can take them into account in your plan. DM Dermatology is a 2-minute walk from Apgujeong Station (Line 3) Exit 5.
CONSULTATION
Consultation comes first
Before any treatment is chosen, a board-certified dermatologist checks your skin in person.
DM Dermatology, 4F, 579-1 Sinsa-dong, Gangnam-gu, Seoul
From Apgujeong Station (Line 3) Exit 5, walk straight for 50 m. 4th floor of the A Twosome Place building
- Weekdays
- am 10:00 - pm 07:00
- Saturday
- am 10:00 - pm 04:30
- Lunch break
- pm 01:00 - pm 02:00
- Sun & holidays
- By appointment only
- Subway
3Apgujeong StationExit 5
Walk straight for 50 m · 2 min on foot · 4th floor of the A Twosome Place building
- Bus
Apgujeong Station Exit 4 · Exit 32310523429
Blue bus147 · 148 · 240 · 463 · 343Green bus4211
Kwanglim Church · Hyundai High School2310323104
Blue bus143 · 240 · 345 · 472Green bus3011 · 4312 · 4318
- By car
Search in your navigation app158 Apgujeong-ro, Gangnam-gu디엠피부과의원
Use the building’s underground parking · Parking available in the building
