
DM DERMATOLOGY
Radiesse
ABOUT RADIESSE
Radiesse, which supports collagen
with calcium microspheres
Radiesse is an injection that places very small particles made of calcium hydroxylapatite (CaHA), suspended in a gel, under the skin. Injected undiluted, it fills volume in hollow areas; diluted and spread widely, it is used as a skin booster.

Hydroxylapatite is the same substance as the mineral that makes up bones and teeth. Radiesse synthesizes this substance into round particles (calcium microspheres) and suspends them evenly in a soft gel. After the gel is absorbed, the body makes new collagen around the remaining microspheres.
Radiesse is a Merz product. Its ingredients differ from hyaluronic acid filler, so it does not dissolve with Hyalase. That is why we carefully decide the areas and amount before treatment.
At DM Dermatology in Apgujeong, we first look at your areas of concern and skin thickness at your visit. Then we decide the goal: filling volume, or skin texture and elasticity, and plan the amount and intervals. Results and recovery vary from person to person.
- Calcium hydroxylapatite (CaHA)
- Volume filling · Skin texture and elasticity
- Does not dissolve with Hyalase
25–45µm
Diameter of the calcium microspheres (finer than a hair)
4–6wk
When texture changes start to show after diluted treatment
2–3sessions
Typical number of sessions for texture and elasticity
12–18months
Typical duration for volume filling

CHECK
If you have these concerns,
consider Radiesse
- Hollow cheeks and deepening nasolabial folds
The front of my cheeks has hollowed and my nasolabial folds have deepened, so my face looks tired.
- A blurred jawline
The line under my jaw is not defined, and from the side my facial contour looks like it has lost its shape.
- Thin, loose skin
The skin on my cheeks and around my mouth has thinned. When I smile, fine lines overlap, and my skin feels less firm.
- Fine lines on the neck and upper chest
The skin on my neck and upper chest (décolletage) looks like crumpled paper.
- Bony-looking backs of the hands
The skin on the backs of my hands has thinned, so tendons and veins stand out.
- Curious about another approach
I want to know about an approach that supports collagen production with an ingredient different from hyaluronic acid filler.
The treatment areas and method are decided together after an examination.
HOW IT WORKS
How calcium microspheres
become a scaffold for new collagen
Calcium microspheres are 25–45 µm in diameter, finer than a strand of hair. The microspheres are spread evenly in a gel carrier made of water, glycerin, and carboxymethylcellulose (CMC). Right after injection, this gel holds the microspheres in place and fills volume.
The gel is absorbed over a few weeks to 3 months, and the microspheres stay in place. When fibroblasts, the cells that make collagen in the dermis, contact the microspheres, they are stimulated. At first, fine type III collagen forms, and over several months it is replaced by firmer type I collagen. Increases in elastic fibers and small blood vessels have also been reported.
Over time, the microspheres break down slowly in the body. As they break down, they become calcium and phosphate ions, which the body processes through its metabolic pathways. It is not a filler material that stays in the body indefinitely.

- 1
Epidermis The outermost layer of the skin. Radiesse is placed not in the epidermis but in the deeper layers below it.
- 2
Collagen fibers Protein fibers that support the dermis. New fibers are added around the microspheres.
- 3
Calcium microspheres Round particles made of CaHA. They remain after the gel is absorbed and become a scaffold where new collagen grows.
- 4
Fibroblasts Cells that make collagen and elastic fibers (elastin). They are stimulated when they contact the microspheres.
- 5
Subcutaneous fat The fat layer below the dermis. To fill volume, Radiesse is sometimes placed in this layer or just above the bone.
TWO WAYS
The same Radiesse,
two uses
Undiluted, the microspheres are densely packed and create volume where they are placed. Thinned with saline (diluted) and spread widely, it creates almost no volume and helps collagen production across a wide area of the skin's foundation.
It is the same product, but the goal, injection depth, and degree of dilution differ. Both methods are sometimes used within one treatment plan.
COURSE
How things change
over time after Radiesse
- Right after injection
When injected undiluted, the gel and microspheres fill the area, so the shape shows right away. When diluted and spread widely, there is almost no change in volume.
- 1–2 weeks
Swelling and redness usually settle within 1 week, and bruising within 1–2 weeks. The shape from undiluted filling is assessed around this time, after the swelling goes down.
- Around 4–6 weeks
New collagen starts to form around the microspheres. With diluted treatment, texture changes may begin to show from around this time, and the next session is scheduled.
- Around 3 months
Most of the gel carrier is absorbed, and collagen gradually fills its place. New collagen settles in over several months.
- 12–18 months
Changes from volume treatment usually last until around this time. The microspheres break down slowly, and we discuss maintenance treatment again at this point.
This is the general course. The timing and degree of change vary from person to person with age, skin thickness, area, and the amount injected.
COMPARE
Radiesse vs. hyaluronic acid filler
| Radiesse (CaHA) | Hyaluronic acid (HA) filler | |
|---|---|---|
| Ingredients | Calcium hydroxylapatite microspheres + gel carrier | A gel made by cross-linking hyaluronic acid |
| How it works | The gel fills volume first, then new collagen forms around the microspheres | The gel itself holds water and fills volume |
| When changes show | Undiluted: right after injection Diluted: from around 4–6 weeks | From right after injection |
| Duration | For volume, usually 12–18 months | Common products: usually 6–12 months (longer for some products and areas) |
| Dissolving with Hyalase | Does not dissolve | Dissolves |
| DM Dermatology menu | Skin Boosters ▸ Radiesse | Filler ▸ Restylane (imported) · Chaeum (Korean-made) |
This table places ingredients and actions side by side. It does not mean one is better. We choose the one that fits the area and goal together at your visit.
PROCESS
Radiesse
treatment process
Below is the general flow. We explain the actual steps and method after your examination.
01Examination and setting the goal
We look at your areas of concern and skin thickness and set the goal: filling volume, or skin texture and elasticity. We ask about allergies (including to lidocaine), medications, keloids, pregnancy or breastfeeding, and past filler.
02Marking the areas
While you sit and look in a mirror, we mark on the skin where to inject and where to avoid.
03Disinfection, numbing, and injection
We remove your makeup and disinfect the skin, apply numbing cream, and wait 20–30 minutes. Using a fine needle or a blunt-tipped cannula, we inject small portions at the set depth.
04Smoothing it evenly
The doctor gently presses the treated area to smooth it so the product does not gather in one spot.
05Soothing and going home
After soothing with a cold pack, we check your skin color and pain, explain aftercare, and you go home.
INFORMATION
What to know
before your treatment
- Procedure time
- 15–30 min of injection
With numbing cream, it takes 20–30 more minutes - Numbing
- Numbing cream 20–30 min
A product containing an anesthetic (lidocaine) reduces the sting during injection - Recovery (swelling · bruising)
- Swelling and redness usually within 1 week; bruising 1–2 weeks
Tenderness when pressed may last a few days - Daily life
- Face washing the same evening; makeup from the next day
Avoid intense exercise, saunas, and strong sunlight for at least 24 hours, until the swelling goes down, and skip alcohol for 2–3 days - Interval · Sessions
- 2–3 sessions, 4–8 weeks apart
For texture and elasticity (diluted). Volume filling is 1 session as standard, with a top-up after 4 weeks if needed - Duration
- Usually 12–18 months
For volume filling; it sometimes lasts up to 24 months. For texture and elasticity (diluted), about 1 year, and 1 maintenance session every 12–18 months is sometimes done
These are general guidelines and vary from person to person. DM Dermatology sets your treatment schedule after an examination.
Caution
Aftercare and
what you should know
Reduce heat and irritation to the treated area until swelling and redness settle.

- 01Avoid heat and exercise for 24 hours
For at least 24 hours, and until swelling and redness go down, avoid intense exercise, saunas, hot baths, and strong sunlight.
- 02Cold compress for swelling
Wrap a cold pack in a towel and apply it for 10–15 minutes at a time. Do not put ice directly on the skin.
- 03Follow the clinic's instructions for injection sites
Do not rub or press hard on the injection sites. Follow the clinic's instructions on whether to massage at home.
- 04Other treatments after the swelling goes down
Laser, radiofrequency, or peels on the same area are scheduled after swelling and redness settle. If you have dental treatment or a vaccination scheduled, please tell us in advance.
- 05Do not stop medications on your own
Aspirin or blood-thinning medicines can increase bruising. Talk with the prescribing doctor first about whether to stop them.
- 06Contact us right away about warning signs
If pain keeps getting worse or your skin turns white or purplish, contact the clinic right away. Detailed warning signs are listed in the side-effect information below.
- Swelling, bruising, redness, tenderness, and itching may occur at injection sites. These usually settle within 1–2 weeks.
- Among Radiesse's adverse reactions, a common one is small lumps (nodules). Most are product that has gathered in one spot and can be felt, and they form more easily in areas that move a lot, such as the lips or around the eyes. The US product labeling states that safety and effectiveness in the lips and around the eyes have not been established, and it also includes reports of nodules in the lips. Lumps on the backs of the hands can last up to 1 year.
- If a less diluted product is placed shallowly where the skin is thin, lumps may be felt or visible. These reactions are more likely in thin skin or darker skin tones. So we set the depth and degree of dilution to match your skin thickness.
- Very rarely, the injected material can block a blood vessel and damage the skin (necrosis) or cause vision problems. If, during or after treatment, pain keeps getting worse, the skin turns pale white, or a purplish net-like pattern appears, contact the clinic right away. If your vision becomes blurry or you cannot see, or your speech becomes slurred and one arm or leg feels weak, call 119 (emergency services in Korea) or go to the nearest emergency room.
- Radiesse does not dissolve with Hyalase (hyaluronidase). Unlike hyaluronic acid filler, there is no treatment that dissolves it to reverse it. Long-lasting lumps are reduced by injecting medication or, rarely, removed through an incision.
- Rarely, a bacterial infection may develop at the injection site. If you have had cold sores, they may come back after treatment. After an infection such as a cold, a vaccination, or dental treatment, the treated area sometimes swells and turns red later on.
- Calcium microspheres show clearly on CT scans and may also show on ordinary X-rays. When you have imaging tests, tell the doctor and the radiology department where and when you had Radiesse. If you had it on the upper chest, also mention it at mammography.
- Treatment is not given if you are allergic to any of its ingredients, have had anaphylaxis (a severe allergy with shock), or have a condition that makes bleeding hard to stop. Products containing lidocaine are not used if you are allergic to local anesthetics such as lidocaine. Allergic reactions are rare.
- Please tell us before treatment if any of the following apply: pregnancy or breastfeeding (safety not established), a tendency to form keloids or hypertrophic scars, inflammation or infection in the treatment area (no treatment until it heals), taking aspirin or blood-thinning medicine, or past filler.
The timing of changes, how long they last, and recovery time vary from person to person with age, skin thickness, area, and the amount injected.

DM DOCTOR
A board-certified dermatologist first checks
your skin thickness and how deep the hollows are
Radiesse is an injection that is hard to reverse by dissolving. That is why we first decide the areas, amount, and degree of dilution at your visit.
Dr. Shin Young-ik Medical Director · Board-Certified Dermatologist
- M.S., Hanyang University College of Medicine
- Adjunct Professor, Hanyang University
- Full Member, Korean Dermatological Association
- Clinical Fellowship in Dermatology, Jefferson Medical College (Thomas Jefferson University), USA
FAQ
01When will I see Radiesse results?
When volume is filled undiluted, the shape shows right after injection. For the first few days it is mixed with swelling, so we look at the result 1–2 weeks later, after the swelling goes down. With the diluted skin booster method, collagen takes time to form, so changes begin to show from around 4–6 weeks.
02How long does Radiesse last?
For volume filling, it usually lasts 12–18 months, and sometimes up to 24 months. For diluted treatment aimed at texture and elasticity, many people have it again after about 1 year. It varies from person to person with age, skin condition, area, and the amount injected.
03Does Radiesse hurt?
Because it is an injection, you will feel stinging and a dull ache. We usually start after applying numbing cream for 20–30 minutes, and a product containing an anesthetic (lidocaine) is sometimes used. For a few days after treatment, the area may hurt when pressed. We explain DM Dermatology's numbing method at your visit.
04How is Radiesse different from hyaluronic acid filler?
Hyaluronic acid filler works by the gel itself filling volume. With Radiesse, the gel fills volume at first, and over time new collagen forms around the calcium microspheres. Hyaluronic acid filler can be dissolved with Hyalase, but Radiesse does not dissolve. Rather than one being better, the choice depends on the area and goal.
05Can Radiesse be dissolved?
It cannot be dissolved. Hyalase is an enzyme that breaks down only hyaluronic acid, so it does not act on Radiesse, which is calcium-based. Small lumps usually shrink over time; if they last, medication is injected or, rarely, they are removed through an incision. A drug that dissolves calcium (sodium thiosulfate) has been discussed, but test results are mixed, so it is not an established treatment.
06What side effects can Radiesse have?
Common reactions are swelling, bruising, redness, tenderness, and itching, which usually settle within 1–2 weeks. A common adverse reaction is small lumps (nodules), which form more easily in areas that move a lot, such as the lips. Rarely, infection, allergy, or a complication that blocks a blood vessel can occur, so learn the warning signs after treatment in advance.
07How many Radiesse sessions do I need?
With the diluted skin booster method, a common schedule is 2–3 sessions, 4–8 weeks apart, and sometimes 1 maintenance session every 12–18 months after that. Volume filling is 1 session as standard, with a top-up after 4 weeks if needed. DM Dermatology sets your schedule after an examination.
08How is Radiesse used as a skin booster different?
It is the same Radiesse, thinned with saline and spread widely and thinly just below the dermis. It aims at skin texture and elasticity rather than creating volume. Diluted use on the face and neck is a method based on expert consensus.
09Can I get Radiesse together with other treatments?
Radiesse is sometimes planned together with hyaluronic acid filler, Botox (botulinum toxin), and ultrasound or radiofrequency lifting. When a heat-based treatment is done on the same area, the order and intervals are set in advance. Please tell us at your visit about recent treatments and any treatments you have scheduled.
10Can I have an X-ray, CT, or MRI after Radiesse?
You can have these tests, but you need to tell them in advance. Calcium microspheres show clearly on CT and may also show on ordinary X-rays, so the US product labeling says to tell your doctor and the radiology department. There are also reports of the treated area showing on MRI images. At your test, tell them where and when you had Radiesse.
CONSULTATION
Consultation comes first
Before any treatment is chosen, a board-certified dermatologist checks your skin in person.
DM Dermatology, 4F, 579-1 Sinsa-dong, Gangnam-gu, Seoul
From Apgujeong Station (Line 3) Exit 5, walk straight for 50 m. 4th floor of the A Twosome Place building
- Weekdays
- am 10:00 - pm 07:00
- Saturday
- am 10:00 - pm 04:30
- Lunch break
- pm 01:00 - pm 02:00
- Sun & holidays
- By appointment only
- Subway
3Apgujeong StationExit 5
Walk straight for 50 m · 2 min on foot · 4th floor of the A Twosome Place building
- Bus
Apgujeong Station Exit 4 · Exit 32310523429
Blue bus147 · 148 · 240 · 463 · 343Green bus4211
Kwanglim Church · Hyundai High School2310323104
Blue bus143 · 240 · 345 · 472Green bus3011 · 4312 · 4318
- By car
Search in your navigation app158 Apgujeong-ro, Gangnam-gu디엠피부과의원
Use the building’s underground parking · Parking available in the building






