DM DERMATOLOGY
Re2O
ABOUT Re2O
A skin booster made from
the dermis of donated skin
Re2O is a human tissue skin booster made by removing the cells from the dermis of donated human skin and then grinding it finely.
Re2O is made by L&C Bio and supplied in Korea by Humedix. It is sold as 'Elravie Re2O.' It was launched in Korea in November 2024. The raw material is human acellular dermal matrix (hADM), and the product box is labeled 'human tissue product.'
Re2O is not a product approved as a drug or medical device. In Korea, it is supplied as human tissue under the tissue bank licensing system. At the October 2026 National Assembly audit, Korea's Ministry of Food and Drug Safety (MFDS) said it would revise this regulatory system. Before deciding on treatment, please first look at the raw material and how it is regulated.
At DM Dermatology in Apgujeong, we first look at your skin condition and medical history at your appointment. Then we decide on the product, the amount injected, and the interval. Results and recovery vary from person to person.
- Human acellular dermal matrix (hADM)
- Powder form
- Human tissue product
- Into the dermis
IN NUMBERS
Re2O in numbers
Product
150mg
Amount in the standard Re2O product,
per the maker's product listLine-up
3products
Products disclosed by the maker
(Standard · Fine · V)Subjects
20people
Participants in the split-face
comparison study published in 2026Follow-up
20wk
Follow-up period
of the same study
Sources for the numbers: L&C Bio product list and press releases; Int J Mol Sci 2026;27(5):2193.
CHECK
If you have these concerns,
check with us at an appointment first
If any of these apply, we look at your skin condition and the product information together during the consultation.
- Case01
The skin on my cheeks looks rough
When I look at my cheeks at an angle, the texture is uneven, and my makeup often looks cakey. - Case02
The product names are confusing
I want to know how Re2O, Re2O Fine, and Re2O V differ. - Case03
I wonder how it differs from Cellre DM
Both are said to be made from human dermis. I want to know how the makers and product lineups differ. - Case04
I want to check the regulatory category first
Before I choose, I want to know how human tissue products are regulated and what the MFDS is reviewing. - Case05
I wonder what to tell you before treatment
If I take medication or have allergies or an autoimmune disease, I want to have it checked at an appointment first.
HOW IT IS MADE
Finely ground particles
of acellular dermis
Re2O's raw material is human acellular dermal matrix. It is allogeneic, which means it comes from another human. It is made by removing the cells from the dermis of donated skin, leaving only the framework components that supported the skin. The maker describes Re2O as this material ground very finely. It names collagen, elastin, proteins, and proteoglycans as the remaining components. Proteoglycans are proteins with sugar chains attached, and they hold water.
Re2O is supplied in powder form. It is mixed with liquid right before treatment and then injected. In the published study, 150mg was mixed with 1.5mL of hyaluronic acid, 2.1mL of saline, and 0.4mL of lidocaine, a local anesthetic, to make 4.0mL. We explain the liquid and amounts DM Dermatology uses during the consultation.
The maker explains that Re2O does not work by stimulating collagen production, but by adding extracellular matrix components directly to the dermis. The extracellular matrix is the structural material that fills the spaces between cells in the dermis.
- 1
Epidermis The outermost layer of the skin. The injection passes through this layer into the dermis below.
- 2
Dermis The layer under the epidermis that is responsible for the skin's elasticity and thickness. In the published study, it was injected at mid-dermal depth.
- 3
Collagen fibers Protein fibers that make up most of the extracellular matrix in the dermis. They are also the main component left in Re2O's raw material.
- 4
Fibroblasts Cells in the dermis that produce collagen and elastin.
- 5
hADM particles Finely ground particles of dermis with the cells removed. They are mixed with liquid right before treatment and placed in small portions in the dermis.
CLINICAL STUDY
How the published study
was designed
In February 2026, a study using Re2O was published in an international journal (International Journal of Molecular Sciences). It was conducted by a research team at Yonsei University Severance Hospital from November 2024 to May 2025.
The researchers reported larger changes on the side that received the Re2O mixture for several measures. The authors wrote that because the test side also contained hyaluronic acid, the effect of Re2O alone could not be separated. The test product was provided by the maker, and the corresponding author disclosed serving as an adviser on the product's development.
Subjects
20 adults
Adults aged 30–65 with moderately rough cheek texture took part.
Split-face
Split-face comparison
One side received a mixture of Re2O and hyaluronic acid; the other side received hyaluronic acid only. Sides were assigned at random, and neither participants nor evaluators knew which side was which.
20 weeks
7 measurements over 20 weeks
Skin density, skin volume, hydration, pore area, elasticity, wrinkles, and cheek texture scores were measured.
Safety
Adverse events
No serious adverse events were reported. There was temporary redness and mild swelling, which settled without treatment.
These results come from study conditions. Individual results vary with skin condition.
PRODUCT FACTS
Product facts:
Cellre DM and Re2O
This table is based on maker materials and news reports. It does not mean that one is better than the other. Which product to use is decided at your appointment based on your skin condition.
PROCESS
Re2O
treatment process
The method and time vary with your skin condition. We explain the details during the consultation.
Examination and consultation
We look at your skin texture, skin thickness, and areas of concern. We ask about your medications, allergies, autoimmune diseases, pregnancy or breastfeeding, and recent treatments. If you have questions about the raw material or regulatory category, please ask at this time.
Cleansing and numbing
We remove your makeup and disinfect your face. Numbing is applied to reduce the sting. We explain the numbing method and time during the consultation.
Mixing and injection
The powdered Re2O is mixed with liquid to make it ready for injection. It is then placed in small amounts at many points in the dermis. During the consultation, we explain the type and amount of liquid, and whether we inject by hand or with an injection device.
Soothing and going home
If needed, we cool the treated area with a cold pad. You go home after we explain the aftercare precautions.
INFORMATION
Re2O treatment info
- Procedure timeInjection 20–30 minPlus about 30 min for numbing cream
- NumbingNumbing creamReduces the stinging sensation
- RecoveryRedness · swelling 1–2 daysAbout 1 week if bruising occurs
- Daily lifeMakeup from the next daySkip saunas and alcohol for a few days
- Interval · Sessions3 sessions, 4 weeks apartAdjusted to your skin condition
These are general guidelines and vary from person to person. DM Dermatology sets your treatment schedule after an examination.
Caution
Aftercare and precautions
after Re2O
Let your skin rest until redness and swelling settle.
- 01Don't touch the injected areas
On the day of treatment, do not press or rub the area with your hands. Skip facial massage and massage devices for a few days.
- 02Cleansing and makeup
On the evening of treatment, wash gently with lukewarm water. Makeup can typically start lightly from the next day.
- 03Avoid heat and sweat
Until the swelling goes down, avoid saunas, jjimjilbang (Korean spas), hot baths, exercise that makes you sweat a lot, and alcohol.
- 04Block the sun
Before going out, apply sunscreen and wear a hat or use a sunbrella. Take extra care while redness remains.
- 05Tell us about other treatment plans
The timing of the next session is set based on your progress. If you plan other treatments such as laser or filler in the meantime, please tell us in advance.
- 06Contact us right away about warning signs
If pain keeps getting worse, the area becomes swollen and hot, or the skin turns white or purplish, contact the clinic right away.
- Redness, swelling, warmth, itching, or tenderness when pressed may occur where you were injected. Needle marks and bruising may be visible. These usually fade within a few days, and bruising may last 1–2 weeks.
- Small bumps or lumps you can feel (nodules) may form at injection sites. They usually shrink over time, but rarely they last for months or need treatment. At the October 2026 National Assembly audit, inflammation, nodules, redness, swelling, and pigment changes were raised as adverse reactions to ECM skin boosters.
- Rarely, a bacterial infection may occur at an injection site. If you have had cold sores (lip herpes), blisters may come back after treatment. Brown pigment may remain where inflammation has passed (post-inflammatory hyperpigmentation), and this is more likely with darker skin tones.
- Re2O is tissue that comes from humans. Even after processing to remove the cells, allergic or immune reactions may rarely occur. Donor screening and infection testing greatly lower the risk of disease transmission, but they cannot reduce that risk to zero.
- With facial injections, very rarely the injected material can block or press on a blood vessel. This can damage the skin (necrosis) or cause vision problems. If pain gets steadily worse, the skin turns pale or shows a purplish net-like pattern, or your vision becomes dim, contact the clinic immediately.
- Please tell us before treatment if you are pregnant or breastfeeding, have an autoimmune disease, or have had a severe allergy or anaphylaxis. Please also tell us about keloids or hypertrophic scars on the face, and any inflammation or infection in the treatment area. The published study excluded people in these groups.
- Blood-thinning medications such as aspirin or anticoagulants can increase bruising and bleeding. Do not stop any medication on your own; talk to the doctor who prescribed it first.
Whether changes appear, how long they last, and how long recovery takes vary from person to person, depending on skin condition and lifestyle habits.
DM DOCTOR
A board-certified dermatologist as medical director
Personal diagnosis · Accountable care
Thorough care from a board-certified dermatologist with over 20 years of treating skin
At DM Dermatology, our medical director, a board-certified dermatologist, examines your skin in person and plans treatment around your concerns and daily life.
Dr. Shin Young-ik Medical Director · Board-Certified Dermatologist
- M.S., Hanyang University College of Medicine
- Adjunct Professor, Hanyang University
- Full Member, Korean Dermatological Association
- Clinical Fellowship in Dermatology, Jefferson Medical College (Thomas Jefferson University), USA
Care by a board-certified dermatologistPatients here are seen by a dermatologist certified by the Ministry of Health and Welfare
DM DERMATOLOGY
Related treatments
FAQ
01What is Re2O made from?
Re2O's raw material is human acellular dermal matrix (hADM). It is made by removing the cells from the dermis of donated human skin, keeping framework components such as collagen and elastin, and turning it into a powder. The maker, L&C Bio, has stated that it uses tissue from overseas donors who consented to cosmetic use.
02Is Re2O approved by Korea's MFDS?
Re2O does not have drug or medical device approval; it is a human tissue product supplied under the tissue bank licensing system. Tissue bank licensing regulates donor screening, infection testing, processing facilities, and quality; it does not review cosmetic effects. At the October 2026 National Assembly audit, the MFDS said it would study and revise this regulatory system.
03Has research confirmed the effects of Re2O?
In 2026, an international journal published a split-face comparison study that followed 20 adults for 20 weeks. One cheek received a mixture of Re2O and hyaluronic acid, and the other received hyaluronic acid only. The researchers reported larger changes on the Re2O side for several measures, but wrote that because hyaluronic acid was also included, the effect of Re2O alone could not be separated. Individual results vary with skin condition.
04How is Re2O different from Cellre DM?
Both are human tissue skin boosters made from human acellular dermal matrix. Re2O is made by L&C Bio, and Cellre DM by Hans Biomed. The product lineup, particle size, and amount per product also differ by company. This does not mean one is better than the other; which product to use is decided at your appointment.
05How is Re2O different from Rejuran?
Rejuran's main ingredient is DNA fragments (polynucleotides, PN) obtained from salmon and other sources, and it is regulated as a medical device in Korea. Re2O's raw material is extracellular matrix from the dermis of human skin, and it is regulated as human tissue. They differ in raw material and regulatory category; we cannot say that one is better than the other.
06What are Re2O Fine and Re2O V?
They are products from the same company with different particle sizes. Re2O Fine is a 50mg product, and the maker states its average particle size is about 50µm (0.05mm). Re2O V has particles more than twice as large as the standard product and was unveiled at an event for medical professionals in October 2026. We explain which product DM Dermatology uses during the consultation.
07What are the side effects of Re2O?
Redness, swelling, bruising, and small lumps (nodules) at injection sites are common reactions. Rarely, infection, pigmentation, or allergic or immune reactions may occur, and because it is human tissue, a very small risk of disease transmission remains. Very rarely, vascular complications may occur, so contact us right away if pain gets worse or your skin changes color.
08Does Re2O hurt?
Because it is injected many times with a needle, you will feel a stinging sensation. Treatment is typically done after numbing cream is applied, and in the published study, a local anesthetic (lidocaine) was added to the mixing liquid. How much it hurts varies by person and area, and we explain DM Dermatology's numbing method during the consultation.
09How many Re2O sessions do I need, and how far apart?
The interval and number of sessions are set based on your skin condition and areas of concern. The clinical trial registration for the study above lists 3 injections one month apart. This schedule reflects the study conditions; DM Dermatology explains your plan after an examination.
10What should I tell DM Dermatology in Apgujeong before getting Re2O?
Please tell us about medications you take (especially aspirin or anticoagulants), allergies, autoimmune diseases, and whether you are pregnant or breastfeeding. If you also tell us about cold sores (lip herpes), keloids, and recent filler, Botox (botulinum toxin), or laser treatments, we will take them into account in your plan. If you are concerned that the product is made from human tissue, feel free to ask at your appointment.
CONSULTATION
Consultation comes first
Before any treatment is chosen, a board-certified dermatologist checks your skin in person.
DM Dermatology, 4F, 579-1 Sinsa-dong, Gangnam-gu, Seoul
From Apgujeong Station (Line 3) Exit 5, walk straight for 50 m. 4th floor of the A Twosome Place building
- Weekdays
- am 10:00 - pm 07:00
- Saturday
- am 10:00 - pm 04:30
- Lunch break
- pm 01:00 - pm 02:00
- Sun & holidays
- By appointment only
- Subway
3Apgujeong StationExit 5
Walk straight for 50 m · 2 min on foot · 4th floor of the A Twosome Place building
- Bus
Apgujeong Station Exit 4 · Exit 32310523429
Blue bus147 · 148 · 240 · 463 · 343Green bus4211
Kwanglim Church · Hyundai High School2310323104
Blue bus143 · 240 · 345 · 472Green bus3011 · 4312 · 4318
- By car
Search in your navigation app158 Apgujeong-ro, Gangnam-gu디엠피부과의원
Use the building’s underground parking · Parking available in the building
